您的位置:365bet体育在线滚球 > 天下奇观 > 化学与分子科学学院

化学与分子科学学院

发布时间:2019-07-23 01:24编辑:天下奇观浏览(141)

    告知标题:Surface Ligand in Modification and Assembly ofMultifunctional Nanoparticles for Biomedical Applications

    报告人:凌代舜教师(黄河大学,国家青少年千人安顿入选者)

    时间:2016年6月13号下午3:00

    地点:化西210会议室

    摘要:Nanotechnology has received extraordinary attention recently due to its burgeoning role in pharmaceutical research. The materials composing the nanoparticles produce fascinating and diversefunctionalities as a result of their exceptionally small size. Size control, both during synthesis andin particle suspensions, is a sine qua non for functionality. This can be accomplished by maskingthe particle surface with a multitude of different ligands [1, 2]. Ligands are essentially fungibleand can be exchanged at various times to confer the desired properties to the particle. This caninclude protecting the particle from harsh aqueous conditions [3, 4], such as pH extremes,maximizing optical properties for diagnostics or shielding the particle from potentially hostileconditions found in the body. The design of the ligand can have crucial effects on biodistributionas well as evasion of biological defenses. Ligands can even be designed to provide newfunctionality in response to various environmental stimuli to improve their therapeutic ordiagnostic capabilities [5, 6]. Clever combination of different nanoscale materials via ligand directed self-assembly will lead to the development of multifunctional nano-biomedical platformsfor advanced drug delivery system such as simultaneous targeted delivery, fast diagnosis, and efficient therapy [7-11].

    [1] D. Ling et al. Surface ligands in synthesis, modification, assembly and biomedical applications of nanoparticles Nano Today, 9:457–477, 2014.

    [2] D. Ling et al. Chemical design of biocompatible iron oxide nanoparticles for medical applications. Small, 9:1450-1466, 2013.

    [3] D. Ling et al. Multiple‐Interaction Ligands Inspired by Mussel Adhesive Protein: Synthesis of Highly Stable and Biocompatible Nanoparticles. Angew. Chem.Int. Ed., 50, 11360–11365, 2011.

    [4] D. Ling et al.A General Strategy for Site‐Directed Enzyme Immobilization by Using NiO Nanoparticle Decorated Mesoporous Silica. Chem. Eur. J., 20:7916 – 7921,2014.

    [5] D. Ling et al. Cancer imaging: Lighting up tumours. Nature Mater.,13, 122-124,2014.

    [6] D. Ling et al. pH-Sensitive NanoformulatedTriptolide as a Targeted Therapeutic Strategy for Hepatocellular Carcinoma. ACS Nano, 8:8027–8039, 2014.

    [7] D. Ling et al. Multifunctional tumor pH-sensitive self-assembled nanoparticles for bimodal imaging and treatment of resistant heterogeneous tumors. J. Am. Chem. Soc., 2014, 136, 5647–5655

    [8] Michael A. Boles, Daishun Linget al. The surface science of nanocrystals, Nature Materials, in press

    [9] D. Ling et al. Photodynamic efficacy of photosensitizers under an attenuated light dose via lipid nano-carrier-mediated nuclear targeting. Biomaterials, 21:5478-5486, 2012.

    [10] D. Ling et al. Chemical synthesis and assembly of uniformly sized iron oxide nanoparticles for medical applications. Acc. Chem. Res., 48:1276–1285, 2015.

    [11] Rui Chen, Daishun Ling*et al, Parallel Comparative Studies on Mouse Toxicity of Oxide Nanoparticle- and Gadolinium-Based T1 MRI Contrast Agents, ACS Nano, 2015, 9, 12425-12435.

    本文由365bet体育在线滚球发布于天下奇观,转载请注明出处:化学与分子科学学院

    关键词: 365bet官网