告知标题：Surface Ligand in Modification and Assembly ofMultifunctional Nanoparticles for Biomedical Applications
摘要：Nanotechnology has received extraordinary attention recently due to its burgeoning role in pharmaceutical research. The materials composing the nanoparticles produce fascinating and diversefunctionalities as a result of their exceptionally small size. Size control, both during synthesis andin particle suspensions, is a sine qua non for functionality. This can be accomplished by maskingthe particle surface with a multitude of different ligands [1, 2]. Ligands are essentially fungibleand can be exchanged at various times to confer the desired properties to the particle. This caninclude protecting the particle from harsh aqueous conditions [3, 4], such as pH extremes,maximizing optical properties for diagnostics or shielding the particle from potentially hostileconditions found in the body. The design of the ligand can have crucial effects on biodistributionas well as evasion of biological defenses. Ligands can even be designed to provide newfunctionality in response to various environmental stimuli to improve their therapeutic ordiagnostic capabilities [5, 6]. Clever combination of different nanoscale materials via ligand directed self-assembly will lead to the development of multifunctional nano-biomedical platformsfor advanced drug delivery system such as simultaneous targeted delivery, fast diagnosis, and efficient therapy [7-11].
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